Miami Children's Hospital
Local: 305-666-6511
Toll Free: 800-432-6837
My Kids Patient Portal
Search
Advanced Search

Medical Services
In this section

Medical Information

Studies in Sedated Children

     Bookmark and Share

Case 1 | Case 2 | Case 3 | Case 4

Back to the fMRI Main Menu

Case 1
Patient 2 month-old-girl with hydrocephalus
Paradigm ON: Presentation of mother's voice, pre-recorded, using familiar words
OFF: Nothing. Patient sedated with chloral hydrate
Statistics
Statistical method P Value Z score
T-Test 0.0007 3.4
Image
Activation There is bilateral activation of the precentral gyri and the right superior temporal gyrus. The activation of the motor strip occurs at the level of oral-facial representation. This is supposed to be related with the habituation-dishabituation of high-amplitude sucking in response to lingustic stimuli. This response is of great importance in the preservation of our species.
Case 2
Patient 18 month-old-boy with mild cerebral palsy
Paradigm ON: Presentation of mother's voice, pre-recorded, using familiar words and sounds
OFF: Nothing. Patient sedated with propofol
Statistics
Statistical method P Value Z score
T-Test 0.0005 3.2
Image
Activation Activation of auditory areas are well depicted. There is bithalamic activation. The strong activation of the right parasagital frontal lobe is not well understood.
Case 3
Patient 4 year-old-boy with autism

Paradigm ON: Presentation of flashing lights at 8 Hz, using special goggles
OFF: Nothing. Patient sedated with nembutal
Statistics
Statistical method P Value Z score
T-Test 0.000002 4.0
Image
Activation Coronal cuts. The colored areas in the figure were obtained subtracting ON from OFF. Thus, the result shows "deactivation", which represent hyper extraction of oxygen occurring in the primary visual areas (V1). This finding is consistently found in young children either awake or under sedation.
Case 4
Patient Normal 18 month-old-boy

Paradigm
#1:
ON: Presentation of mother's voice, pre-recorded, using familiar words
OFF: Nothing. Patient sedated with chloral hydrate
Statistics
Statistical method P Value Z score
T-Test 0.0005 3.2
Graphic of Time Course 6 epochs starting in OFF
Image
Activation There is bilateral activation on the parasagital aspects of the frontal lobes, greater on the right. The primary auditory area is activated on the left. Scattered activation is also present on the right parietal lobe. There is bilateral activation of the cuneus and precuneus wider on the left.
Paradigm
#2:
ON: Presentation of flashing lights, 8 Hz
OFF: Nothing. Patient sedated with chloral hydrate
Statistics
Statistical method P Value Z score
T-Test 0.0005 3.3
Image

ON-OFF


OFF-ON

Activation There is bilateral activation of the motor strip, and "deactivation" of anterolateral region of the calcarine fissure (periferal V1) as seen in the case No. 3. The location of this response is expected since the type of stimulus used here causes greater activation of the peripheral retina than of the fovea. The activation of the motor areas through visual stimulus is similar to the obtained with mother's voice in case No. 1.